| Pair Name | Naringenin, Diosmin | ||
| Phytochemical Name | Naringenin (PubChem CID: 439246 ) | ||
| Anticancer drug Name | Diosmin (PubChem CID: 5281613 ) | ||
| Structure of Phytochemical |
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3D
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| Structure of Anticancer Drug |
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| Pair Name | Naringenin, Diosmin | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP8 | hsa841 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| Down-regulation | Expression | CHUK | hsa1147 | |
| Down-regulation | Expression | IKBKB | hsa3551 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 | |
| Result | Diosmin in combination with naringenin enhances apoptosis in colon cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Diosmin in combination with naringenin enhances apoptosis in colon cancer cells. Oncol Rep. 2022 Jan;47(1):4. doi: 10.3892/or.2021.8215. | Click |
